TANK (gene)

TANK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KZZ, 1L0A
Identifiers
Aliases	TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
External IDs	MGI: 107676 HomoloGene: 3081 GeneCards: TANK
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding • metal ion binding • deubiquitinase activator activity • thiol-dependent ubiquitin-specific protease activity Cellular component • cytoplasm • cytosol • protein complex Biological process • TRIF-dependent toll-like receptor signaling pathway • I-kappaB kinase/NF-kappaB signaling • signal transduction • positive regulation of ubiquitin-specific protease activity • positive regulation of protein deubiquitination • cellular response to tumor necrosis factor • negative regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to interleukin-1 • cellular response to DNA damage stimulus • proteolysis • cellular response to ionizing radiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10010	21353
Ensembl	ENSG00000136560	ENSMUSG00000064289
UniProt	Q92844 Q6NW12	P70347
RefSeq (mRNA)	NM_001199135 NM_004180 NM_133484	NM_001164071 NM_001164072 NM_011529
RefSeq (protein)	NP_001186064.1 NP_004171.2 NP_597841.1 NP_001186064.1	NP_001157544.1 NP_035659.1
Location (UCSC)	Chr 2: 161.14 – 161.24 Mb	Chr 2: 61.58 – 61.65 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.^[3][4][5]

Function

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1,^[6][7] IKBKE,^[8] TRAF2,^[3][6][7][8] IKBKG^[9] and TRAF3.^[3][6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
4. Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (October 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 11085–90. doi:10.1073/pnas.93.20.11085. PMC 38288. PMID 8855313.
5. "Entrez Gene: TANK TRAF family member-associated NFKB activator".
6. Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
7. Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
8. Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890.
9. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.

Further reading

• Chin AI, Shu J, Shan Shi C, Yao Z, Kehrl JH, Cheng G (October 1999). "TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway". Molecular and Cellular Biology. 19 (10): 6665–72. PMC 84649. PMID 10490605.
• Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
• Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890.
• Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (June 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR (March 2002). "Downstream regulator TANK binds to the CD40 recognition site on TRAF3". Structure. 10 (3): 403–11. doi:10.1016/S0969-2126(02)00733-5. PMID 12005438.
• Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
• Ishida R, Ezura Y, Emi M, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H (August 2003). "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women". Bone. 33 (2): 237–41. doi:10.1016/S8756-3282(03)00226-6. PMID 14499357.
• Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling". The Journal of Biological Chemistry. 278 (50): 50523–9. doi:10.1074/jbc.M309381200. PMID 14517219.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bonif M, Meuwis MA, Close P, Benoit V, Heyninck K, Chapelle JP, Bours V, Merville MP, Piette J, Beyaert R, Chariot A (March 2006). "TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation". The Biochemical Journal. 394 (Pt 3): 593–603. doi:10.1042/BJ20051659. PMC 1383709. PMID 16336209.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Guo B, Cheng G (April 2007). "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK". The Journal of Biological Chemistry. 282 (16): 11817–26. doi:10.1074/jbc.M700017200. PMID 17327220.
• Ryzhakov G, Randow F (July 2007). "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK". The EMBO Journal. 26 (13): 3180–90. doi:10.1038/sj.emboj.7601743. PMC 1914091. PMID 17568778.
• Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A (October 2007). "Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF". The Journal of Biological Chemistry. 282 (43): 31131–46. doi:10.1074/jbc.M701690200. PMID 17823124.

External links

• TANK human gene location in the UCSC Genome Browser.
• TANK human gene details in the UCSC Genome Browser.