TCF20

TCF20
Identifiers
Aliases TCF20, AR1, SPBP, TCF-20, transcription factor 20 (AR1)
External IDs MGI: 108399 HomoloGene: 4131 GeneCards: TCF20
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

6942

21411

Ensembl

n/a

ENSMUSG00000041852

UniProt

Q9UGU0

Q9EPQ8

RefSeq (mRNA)

NM_005650
NM_181492

NM_001114140
NM_013836

RefSeq (protein)

NP_005641.1
NP_852469.1

NP_001107612.1

Location (UCSC) Chr 22: 42.16 – 42.34 Mb Chr 15: 82.81 – 82.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.[3][4][5]

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.[5]

Interactions

TCF20 has been shown to interact with RNF4.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Rajadhyaksha A, Riviere M, Van Vooren P, Szpirer J, Szpirer C, Babin J, Bina M (October 1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 176–7. doi:10.1159/000015021. PMID 9730594.
  4. Rekdal C, Sjottem E, Johansen T (January 2001). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators". J Biol Chem. 275 (51): 40288–300. doi:10.1074/jbc.M006978200. PMID 10995766.
  5. 1 2 "Entrez Gene: TCF20 transcription factor 20 (AR1)".
  6. Lyngsø, C; Bouteiller G; Damgaard C K; Ryom D; Sanchez-Muñoz S; Nørby P L; Bonven B J; Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". J. Biol. Chem. UNITED STATES. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. ISSN 0021-9258. PMID 10849425.

Further reading


This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.