THSD1

THSD1
Identifiers
Aliases	THSD1, TMTSP, UNQ3010, thrombospondin type 1 domain containing 1
External IDs	MGI: 1929096 HomoloGene: 10264 GeneCards: THSD1
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55901	56229
Ensembl	ENSG00000136114	ENSMUSG00000031480
UniProt	Q9NS62	Q9JM61
RefSeq (mRNA)	NM_199263 NM_018676	NM_001205253 NM_001293688 NM_019576
RefSeq (protein)	NP_061146.1 NP_954872.1	NP_062522.1
Location (UCSC)	Chr 13: 52.38 – 52.41 Mb	Chr 8: 22.23 – 22.26 Mb
PubMed search	[1]	[2]
Wikidata

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Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.^[3]

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: THSD1 thrombospondin, type I, domain containing 1".

Further reading

• Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor". FEBS Lett. 327 (2): 125–30. doi:10.1016/0014-5793(93)80155-N. PMID 7687569.
• Gruber HE, Ingram JA, Hanley EN (2007). "Immunolocalization of thrombospondin in the human and sand rat intervertebral disc". Spine. 31 (22): 2556–61. doi:10.1097/01.brs.0000241117.31510.e3. PMID 17047544.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE (2005). "Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly". J. Biol. Chem. 279 (47): 48983–92. doi:10.1074/jbc.M404881200. PMID 15371459.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.