TIAF1

TIAF1
Identifiers
Aliases	TIAF1, MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1
External IDs	HomoloGene: 130531 GeneCards: TIAF1
Gene ontology Molecular function • molecular function Cellular component • nucleus Biological process • I-kappaB kinase/NF-kappaB signaling • negative regulation of apoptotic process • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9220	n/a
Ensembl	ENSG00000221995	n/a
UniProt	O95411	n/a
RefSeq (mRNA)	NM_004740	n/a
RefSeq (protein)	NP_004731.2	n/a
Location (UCSC)	Chr 17: 29.07 – 29.08 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.^[2][3]

Interactions

TIAF1 has been shown to interact with Janus kinase 3^[4] and TRIB3.^[5]

References

1. "Human PubMed Reference:".
2. Chang NS, Mattison J, Cao H, Pratt N, Zhao Y, Lee C (February 1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem Biophys Res Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
3. "Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1".
4. Ji, H; Zhai Q; Zhu J; Yan M; Sun L; Liu X; Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. UNITED STATES. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. ISSN 0006-291X. PMID 10733938.
5. Zhou, Ying; Li Lu; Liu Qiongming; Xing Guichun; Kuai Xuezhang; Sun Jing; Yin Xiushan; Wang Jian; Zhang Lingqiang; He Fuchu (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. England. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110.

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival.". Biochem. Biophys. Res. Commun. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mori K, Furusawa T, Okubo T, et al. (2004). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A).". J. Biochem. 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.
• van der Leij J, van den Berg A, Albrecht EW, et al. (2003). "High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells.". Transplantation. 75 (12): 2076–82. doi:10.1097/01.TP.0000069829.71088.88. PMID 12829915.
• Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Schultz L, Khera S, Sleve D, et al. (2004). "TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.". DNA Cell Biol. 23 (1): 67–74. doi:10.1089/104454904322745943. PMID 14965474.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain.". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
• Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site.". Biochemistry. 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.