TNIK

TNIK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X7F, 5CWZ, 5AX9
Identifiers
Aliases	TNIK
External IDs	MGI: 1916264 HomoloGene: 77943 GeneCards: TNIK
Genetically Related Diseases
coronary artery disease, schizophrenia[1]
Targeted by Drug
staurosporine[2]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • signal transducer, downstream of receptor, with serine/threonine kinase activity Cellular component • cytoplasm • recycling endosome • endosome • nucleoplasm • apical plasma membrane • extracellular exosome • cytoskeleton • nucleus Biological process • actin cytoskeleton reorganization • microvillus assembly • positive regulation of protein phosphorylation • intracellular signal transduction • phosphorylation • activation of JNKK activity • Wnt signaling pathway • nervous system development • regulation of dendrite morphogenesis • protein phosphorylation • cytoskeleton organization • protein autophosphorylation • protein localization to plasma membrane • xenophagy • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23043	665113
Ensembl	ENSG00000154310	ENSMUSG00000027692
UniProt	Q9UKE5	P83510
RefSeq (mRNA)	NM_001161560 NM_001161561 NM_001161562 NM_001161563 NM_001161564 NM_001161565 NM_001161566 NM_015028	NM_001163007 NM_001163008 NM_001163009 NM_026910
RefSeq (protein)	NP_001155032.1 NP_001155033.1 NP_001155034.1 NP_001155035.1 NP_001155036.1 NP_001155037.1 NP_001155038.1 NP_055843.1	NP_001156480.1
Location (UCSC)	Chr 3: 171.06 – 171.46 Mb	Chr 3: 28.26 – 28.68 Mb
PubMed search	[3]	[4]
Wikidata

View/Edit Human

View/Edit Mouse

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.^[5][6][7]

Function

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.^[6][7]

Interactions

TNIK has been shown to interact with KIAA0090,^[8] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes.^[6]

References

1. "Diseases that are genetically associated with TNIK view/edit references on wikidata".
2. "Drugs that physically interact with TRAF2 and NCK-interacting protein kinase view/edit references on wikidata".
3. "Human PubMed Reference:".
4. "Mouse PubMed Reference:".
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
6. Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem. 274 (43): 30729–37. doi:10.1074/jbc.274.43.30729. PMID 10521462.
7. "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".
8. Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Yonekura H, Migita H, Sakurai S, et al. (1999). "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes.". Nucleic Acids Res. 27 (13): 2591–600. doi:10.1093/nar/27.13.2591. PMC 148466. PMID 10373574.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Taira K, Umikawa M, Takei K, et al. (2005). "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.". J. Biol. Chem. 279 (47): 49488–96. doi:10.1074/jbc.M406370200. PMID 15342639.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.