TPTE

TPTE
Identifiers
Aliases	TPTE, CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDs	GeneCards: TPTE
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • integral component of membrane • membrane Biological process • protein dephosphorylation • signal transduction • dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7179	n/a
Ensembl	ENSG00000274391	n/a
UniProt	P56180	n/a
RefSeq (mRNA)	NM_199261 NM_001290224 NM_199259 NM_199260	n/a
RefSeq (protein)	NP_001277153.1 NP_954868.1 NP_954869.1 NP_954870.2	n/a
Location (UCSC)	Chr 21: 10.52 – 10.61 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.^[2][3]

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.^[3] TPTE is believed to lack phosphatase activity; however, the closely related protein TPIP, also called TPTE2 is an active phosphatase with activity against inositol phospholipid substrates.^[4] TPTE and TPIP are the mammalian homologues to the family of voltage sensitive phosphatases.

References

1. "Human PubMed Reference:".
2. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
3. "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
4. Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.

Further reading

• Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome.". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
• Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804.
• Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21.". Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409.
• Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID 11279206.
• Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family.". Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268.