TRIP4

TRIP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5O
Identifiers
Aliases	TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4
External IDs	MGI: 1928469 HomoloGene: 9426 GeneCards: TRIP4
Genetically Related Diseases
Alzheimer's disease[1]
Gene ontology Molecular function • protease binding • transcription coactivator activity • zinc ion binding • estrogen receptor binding • protein binding • histone acetyltransferase binding • ligand-dependent nuclear receptor binding • ubiquitin-like protein ligase binding • metal ion binding Cellular component • cytoplasm • cytosol • cytoskeleton • nucleus • nucleoplasm • microtubule organizing center • neuromuscular junction • transcription factor complex Biological process • positive regulation of transcription, DNA-templated • toxin transport • intracellular estrogen receptor signaling pathway • transcription, DNA-templated • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9325	56404
Ensembl	ENSG00000103671	ENSMUSG00000032386
UniProt	Q15650	Q9QXN3
RefSeq (mRNA)	NM_016213 NM_001321924	NM_001170907 NM_019797
RefSeq (protein)	NP_057297.2 NP_001308853.1	NP_001164378.1 NP_062771.2
Location (UCSC)	Chr 15: 64.39 – 64.46 Mb	Chr 9: 65.83 – 65.91 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.^[4][5]

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.^[6]

References

1. "Diseases that are genetically associated with TRIP4 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
5. "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
6. Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1.". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
• Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.