TUBGCP6

TUBGCP6
Identifiers
Aliases	TUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDs	MGI: 2146071 HomoloGene: 32477 GeneCards: TUBGCP6
Gene ontology Molecular function • microtubule binding • structural constituent of cytoskeleton • microtubule minus-end binding • gamma-tubulin binding Cellular component • cytoplasm • cytosol • centrosome • spindle pole • equatorial microtubule organizing center • membrane • microtubule organizing center • spindle pole body • gamma-tubulin ring complex • microtubule • extracellular exosome • cytoskeleton Biological process • centrosome duplication • interphase microtubule nucleation by interphase microtubule organizing center • mitotic spindle assembly • cytoplasmic microtubule organization • meiotic nuclear division • microtubule cytoskeleton organization • microtubule nucleation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	85378	328580
Ensembl	ENSG00000128159	ENSMUSG00000051786
UniProt	Q96RT7	G5E8P0
RefSeq (mRNA)	NM_001008658 NM_020461	NM_001163319
RefSeq (protein)	NP_065194.2	NP_001156791.1
Location (UCSC)	Chr 22: 50.22 – 50.24 Mb	Chr 15: 89.1 – 89.12 Mb
PubMed search	[1]	[2]
Wikidata

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Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.^[3][4][5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

• Tubulin
• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP5

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
4. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
5. "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

Further reading

• Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.