TXNDC12

TXNDC12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs MGI: 1913323 HomoloGene: 41074 GeneCards: TXNDC12
Orthologs
Species Human Mouse
Entrez

51060

66073

Ensembl

ENSG00000117862

ENSMUSG00000028567

UniProt

O95881

Q9CQU0

RefSeq (mRNA)

NM_015913

NM_025334

RefSeq (protein)

NP_056997.1

NP_079610.1

Location (UCSC) Chr 1: 52.02 – 52.06 Mb Chr 4: 108.83 – 108.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.[3][4][5]

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors[6] (Liu et al., 2003).[supplied by OMIM][5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  4. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146Freely accessible. PMID 9110174.
  5. 1 2 "Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)".
  6. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6). doi:10.1186/1479-7364-6-6. PMC 3500226Freely accessible. PMID 23245351.

Further reading


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