Tilorone

Tilorone

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (tablets)
ATC code	None
Pharmacokinetic data
Bioavailability	60%
Protein binding	~80%
Metabolism	Nil
Biological half-life	48 hours
Excretion	Feces (70%), urine (9%)[1]
Identifiers
IUPAC name 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number	27591-97-5
PubChem (CID)	5475
ChemSpider	5276
UNII	O6W7VEW6KS
KEGG	D06149
ChEMBL	CHEMBL47298
Chemical and physical data
Formula	C25H34N2O3
Molar mass	410.55 g/mol
3D model (Jmol)	Interactive image
SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 Key:MPMFCABZENCRHV-UHFFFAOYSA-N
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Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[2] It is used as an antiviral drug.

Pharmacology

Tilorone activates the production of interferon.^[2]

According to the results of clinical tests, conducted in Kiev, the efficacy of prophylactic action of tilorone was 93.7%.

Uses

Tilorone is used for different viral diseases: influenza, hepatitis, herpes, diarrhea and others. In addition, it is used in the treatment of multiple sclerosis, urinary tract infections and other viral and autoimmune diseases.

References

1. "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
2. Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 (2): 73–8. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.