Trans-pentaprenyltranstransferase
trans-pentaprenyltranstransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.5.1.33 | ||||||||
CAS number | 83745-07-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a trans-pentaprenyltranstransferase (EC 2.5.1.33) is an enzyme that catalyzes the chemical reaction
- all-trans-pentaprenyl diphosphate + isopentenyl diphosphate diphosphate + all-trans-hexaprenyl diphosphate
Thus, the two substrates of this enzyme are all-trans-pentaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-hexaprenyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase. Other names in common use include all-trans-hexaprenyl-diphosphate synthase, hexaprenyl diphosphate synthase, and hexaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.
References
- Fujii H, Koyama T, Ogura K (1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26 Separation of two essential components". J. Biol. Chem. 257 (24): 14610–2. PMID 7174655.