UNC5C

UNC5C
Identifiers
Aliases UNC5C, UNC5H3, unc-5 netrin receptor C
External IDs MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C
Genetically Related Diseases
obesity[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

8633

22253

Ensembl

ENSG00000182168

ENSMUSG00000059921

UniProt

O95185

O08747

RefSeq (mRNA)

NM_003728

NM_001293561
NM_009472

RefSeq (protein)

NP_003719.3

NP_033498.1

Location (UCSC) Chr 4: 95.16 – 95.55 Mb Chr 3: 141.47 – 141.83 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.[4][5][6]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.[6]

References

  1. "Diseases that are genetically associated with UNC5C view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. doi:10.1038/386833a0. PMID 9126742.
  5. Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.
  6. 1 2 "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".

Further reading


This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.