Ubiquinol oxidase (H+-transporting)
Ubiquinol oxidase (H+-transporting) | |||||||||
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Identifiers | |||||||||
EC number | 1.10.3.10 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Ubiquinol oxidase (H+-transporting) (EC 1.10.3.10, cytochrome bb3 oxidase, cytochrome bo oxidase, cytochrome bd-I oxidase) is an enzyme with systematic name ubiquinol:O2 oxidoreductase (H+-transporting).[1][2][3][4] This enzyme catalyses the following chemical reaction
- 2 ubiquinol + O2 + n H+in 2 ubiquinone + 2 H2O + n H+out
Ubiquinol oxidase contains a dinuclear centre comprising two hemes, or heme and copper.
References
- ↑ Abramson, J.; Riistama, S.; Larsson, G.; Jasaitis, A.; Svensson-Ek, M.; Laakkonen, L.; Puustinen, A.; Iwata, S.; Wikstrom, M. (2000). "The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site". Nat. Struct. Biol. 7: 910–917. doi:10.1038/82824. PMID 11017202.
- ↑ Belevich, I.; Borisov, V.B.; Zhang, J.; Yang, K.; Konstantinov, A.A.; Gennis, R.B.; Verkhovsky, M.I. (2005). "Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site". Proc. Natl. Acad. Sci. USA. 102 (10): 3657–3662. doi:10.1073/pnas.0405683102. PMC 553295. PMID 15728392.
- ↑ Yap, L.L.; Lin, M.T.; Ouyang, H.; Samoilova, R.I.; Dikanov, S.A.; Gennis, R.B. (2010). "The quinone-binding sites of the cytochrome bo3 ubiquinol oxidase from Escherichia coli". Biochim. Biophys. Acta. 1797 (12): 1924–1932. doi:10.1016/j.bbabio.2010.04.011. PMC 2922442. PMID 20416270.
- ↑ Shepherd, M.; Sanguinetti, G.; Cook, G.M.; Poole, R.K. (2010). "Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism". J. Biol. Chem. 285 (24): 18464–18472. doi:10.1074/jbc.M110.118448. PMC 2881772. PMID 20392690.
External links
- Ubiquinol oxidase (H -transporting) at the US National Library of Medicine Medical Subject Headings (MeSH)
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