Giovanni J. Ughi

Giovanni J. Ughi
Born Padova, Italy
Residence U.S.
Nationality Italian
Fields Biomedical Optics
Institutions Harvard University
Alma mater University of Padova; Katholieke Universiteit Leuven; Harvard Medical School;
Known for optical coherence tomography; intravascular fluorescence; Image processing;
Notable awards Bullock-Wellman Postdoctoral Fellowship (2014) - Harvard Medical School[1]

Giovanni J. Ughi (born Padova, Italy), Italian engineer and scientist, is one of the inventors of multimodality Optical Coherence Tomography (OCT) and Laser-induced fluorescence molecular imaging, pioneering a first-in-man study of coronary arteries during his work at Massachusetts General Hospital.[2][3][4] The results of his work, combining two imaging technologies, may better identify dangerous coronary plaques, responsible for coronary artery disease and myocardial infarction.[5][6] He also was one of the pioneers of targeted molecular imaging of human atherosclerosis, determining the use of an FDA approved molecular agent (i.e., indocyanine green (ICG)-enhanced near-infrared fluorescence) that can illuminate high-risk features of human carotid atherosclerosic plaques[7] and other molecular agents for the identification of unhealed stents that are at higher risk of stent thrombosis.[8]

Giovanni J. Ughi also made significant contributions to the development of methods for the computer-based, automated analysis of Intracoronary optical coherence tomography (OCT) images, helping the widespread adoption of intracoronary OCT imaging technology.[9][10][11] He is recognized for the development of methods for the automatic quantification of stent characteristics on intracoronary optical coherence tomography images.[12]

He has co-authored over 40 papers in peer-reviewed scientific international journals.

References

  1. ↑ "2014 Bullock-Wellman Fellowship Award Recipients". Wellman Center for Photomedicine. Retrieved 8 September 2016.
  2. ↑ Neale, Todd (11 March 2016). "Does New Dual-Modality Imaging Come Closer to Uncovering Vulnerable Plaques?". TCTMD. Cardiovascular Research Foundation. Retrieved 13 September 2016.
  3. ↑ Psaltis PJ, Nicholls SJ (2016). "Imaging: Focusing light on the vulnerable plaque". Nature Reviews Cardiology. 13: 253–255. doi:10.1038/nrcardio.2016.53.
  4. ↑ Ughi GJ, Wang H, Gerbaud E, Gardecki JA, Fard AM, Hamidi E, Vacas-Jacques P, Rosenberg M, Jaffer FA, Tearney GJ (2016). "Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging". J Am Coll Cardiol Img. doi:10.1016/j.jcmg.2015.11.020. PMID 26971006.
  5. ↑ "Combining two imaging technologies may better identify dangerous coronary plaques - Adding fluorescence imaging to OCT reveals biological, as well as structural information". Mass General News. Retrieved 7 September 2016.
  6. ↑ "OCT, fluorescence imaging pair to better identify heart attack-prone coronary plaques". 11 March 2016. Retrieved 11 September 2016.
  7. ↑ Verjans JW, Osborn EA, Ughi GJ, Calfon Press MA, Hamidi E, Antoniadis AP, Papafaklis MI, Conrad MF, Libby P, Stone PH, Cambria RP, Tearney GJ, Jaffer FA (2016). "Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis: Clinical and Intracoronary Evaluation of Indocyanine Green". J Am Coll Cardiol Img. 9 (9): 1087–1095. doi:10.1016/j.jcmg.2016.01.034. PMID 27544892.
  8. ↑ Hara T, Ughi GJ, McCarthy JR, Erdem SS, Mauskapf A, Lyon SC, Fard AM, Edelman ER, Tearney GJ, Jaffer FA (2015). "Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo". European Heart Journal. doi:10.1093/eurheartj/ehv677. PMID 26685129.
  9. ↑ Ughi GJ, Van Dyck CJ, Adriaenssens T, Hoymans VY, Sinnaeve P, Timmermans JP, Desmet W, Vrints CJ, D'hooge J. (2014). "Automatic assessment of stent neointimal coverage by intravascular optical coherence tomography". Eur Heart J Cardiovasc Imaging. 15 (2): 195–200. doi:10.1093/ehjci/jet134. PMID 23884965.
  10. ↑ Ughi GJ, Adriaenssens T, Desmet W, D'hooge J (2012). "Fully automatic three-dimensional visualization of intravascular optical coherence tomography images". Biomed Opt Express. 3 (12): 3291–3303. PMC 3521298Freely accessible. PMID 23243578.
  11. ↑ Ughi GJ, Adriaenssens T, Onsea K, Kayaert P, Dubois C, Sinnaeve P, Coosemans M, Desmet W, D'hooge J (2012). "Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage". Int J Cardiovasc Imaging. 28 (2): 229–241. doi:10.1007/s10554-011-9824-3. PMID 21347593.
  12. ↑ "winner of Optical Coherence Tomography Award". 9 January 2011. Retrieved 11 September 2016.

External links

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