William Stapleton
William Stapleton may refer to:
- William Stapleton (died 1432), MP for Cumberland (UK Parliament constituency)
- William Stapleton (MP), MP for Carlisle
- William Stapleton (governor), see List of colonial governors of Nevis
- Sir William Stapleton, 4th Baronet (c.1698–1740), English politician, son of the governor
- William Stapleton (British Army officer) (died 1826), British general
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