Zoxazolamine
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| Clinical data | |
|---|---|
| Routes of administration | Oral |
| Identifiers | |
| |
| Synonyms | McN-485 |
| CAS Number | 61-80-3 |
| PubChem (CID) | 6103 |
| ChemSpider | 5878 |
| UNII | 9DOW362Q29 |
| KEGG | C13841 |
| ChEBI | CHEBI:35053 |
| ChEMBL | CHEMBL472566 |
| Chemical and physical data | |
| Formula | C7H5ClN2O |
| Molar mass | 168.5804 g/mol |
| 3D model (Jmol) | Interactive image |
| |
| |
Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed.[1][2] It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity.[1][2][3] One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine.[3] These drugs activate IKCa channels.[4]
References
- 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 48–. ISBN 978-1-4757-2085-3.
- 1 2 Ashutosh Kar (1 January 2005). Medicinal Chemistry. New Age International. pp. 185–. ISBN 978-81-224-1565-0.
- 1 2 W. Lowry (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 166–. ISBN 978-1-4684-3444-6.
- ↑ Stefan Offermanns. Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 996–. ISBN 978-3-540-38916-3.
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