(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase

(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.247, methyltransferase 2, MT2, MT2-A, mtbA (gene)) is an enzyme with systematic name methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

\rightleftharpoons

methyl-CoM + [Co(I) methylamine-specific corrinoid protein]

This enzyme contains zinc.

References

↑ Burke, S.A.; Krzycki, J.A. (1995). "Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine". J. Bacteriol. 177: 4410–4416. PMID 7635826.
↑ LeClerc, G.M.; Grahame, D.A. (1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". J. Biol. Chem. 271: 18725–18731. doi:10.1074/jbc.271.31.18725. PMID 8702528.
↑ Ferguson, D.J. Jr.; Krzycki, J.A. (1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". J. Bacteriol. 179: 846–852. PMID 9006042.
↑ Burke, S.A.; Lo, S.L.; Krzycki, J.A. (1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". J. Bacteriol. 180: 3432–3440. PMID 9642198.
↑ Ferguson, D.J. Jr.; Gorlatova, N.; Grahame, D.A.; Krzycki, J.A. (2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 275: 29053–29060. doi:10.1074/jbc.m910218199. PMID 10852929.

External links

(methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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