Butyrophenone
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Names | |||
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IUPAC name
1-phenylbutan-1-one | |||
Identifiers | |||
495-40-9 | |||
3D model (Jmol) | Interactive image Interactive image | ||
ChEMBL | ChEMBL193524 | ||
ChemSpider | 9893 | ||
ECHA InfoCard | 100.007.091 | ||
PubChem | 10315 | ||
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Properties | |||
C10H12O | |||
Molar mass | 148.20 g/mol | ||
Appearance | colorles liquid | ||
Melting point | 12 °C (54 °F; 285 K) | ||
Boiling point | 229 °C (444 °F; 502 K) | ||
negligible | |||
log P | 2.77 | ||
Refractive index (nD) |
1.520 | ||
Hazards | |||
NFPA 704 | |||
Flash point | 99 °C (210 °F; 372 K) | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
verify (what is ?) | |||
Infobox references | |||
Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.[1]
Examples of butyrophenones include:
- Haloperidol, the most widely used classical antipsychotic drug in this class[1]
- Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine)[1]
- Nonaperone[2]
References
- 1 2 3 Keith Parker; Laurence Brunton Goodman; Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th ed.). New York: McGraw-Hill. ISBN 0071422803.
- ↑ Grogan, Charles H.; Rice, Leonard M. (1967). "Ω-Azabicyclic Butyrophenones". Journal of Medicinal Chemistry. 10 (4): 621. doi:10.1021/jm00316a022. PMID 6037051.
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