5-MeO-MPMI

5-MeO-MPMI

Identifiers
IUPAC name 5-Methoxy-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole
CAS Number	143321-57-7
PubChem (CID)	9881324
ChemSpider	8057000
ChEMBL	CHEMBL137485
Chemical and physical data
Formula	C15H20N2O
Molar mass	244.332 g/mol
3D model (Jmol)	Interactive image
SMILES CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)OC
InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1 Key:MKEGUJPBCIXABO-GFCCVEGCSA-N
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5-MeO-MPMI (also known as 5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine) is a tryptamine derivative that is a psychedelic drug. It was first developed by the team led by JE Macor in 1992,^[1] and subsequently investigated by the team led by David Nichols from Purdue University in the late 1990s. This compound produces psychedelic-appropriate responding in animal tests with a similar potency to the amphetamine-derived psychedelic DOI, and has two enantiomers, with only the (R)-enantiomer being active.^[2]

See also

• 5-MeO-pyr-T
• 4-HO-MPMI
• 4-HO-pyr-T
• CP-135,807

References

1. Macor JE, Blake J, Fox CB, Johnson C, Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al. (1992). "Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin". Journal of Medicinal Chemistry. 35 (23): 4503–4305. doi:10.1021/jm00101a032. PMID 1447752.
2. Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE (1999). "Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain". Journal of Medicinal Chemistry. 42 (20): 4257–4263. doi:10.1021/jm990325u. PMID 10514296.