ADAMTS10

ADAMTS10
Identifiers
Aliases ADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDs MGI: 2449112 HomoloGene: 81940 GeneCards: ADAMTS10
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

81794

224697

Ensembl

ENSG00000142303

ENSMUSG00000024299

UniProt

Q9H324

P58459

RefSeq (mRNA)

NM_001282352
NM_030957

NM_172619

RefSeq (protein)

NP_001269281.1
NP_112219.3

NP_766207.2

Location (UCSC) Chr 19: 8.58 – 8.61 Mb Chr 17: 33.52 – 33.55 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[3]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[3]

References

Further reading

External links


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