CCL9

Ccl9
Identifiers
Aliases	chemokine (C-C motif) ligand 9CCF18MRP-2Scya10Scya9
External IDs	MGI: 104533 HomoloGene: 86734 GeneCards:
Gene ontology Molecular function • CCR chemokine receptor binding • chemokine activity • cytokine activity Cellular component • extracellular region • extracellular space Biological process • neutrophil chemotaxis • negative regulation of myoblast differentiation • cellular response to tumor necrosis factor • positive regulation of inflammatory response • positive regulation of ERK1 and ERK2 cascade • inflammatory response • positive regulation of GTPase activity • G-protein coupled receptor signaling pathway • lymphocyte chemotaxis • monocyte chemotaxis • cellular response to interferon-gamma • cellular response to interleukin-1 • immune response • chemokine-mediated signaling pathway • chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	20308	20308
Ensembl	ENSMUSG00000019122	ENSMUSG00000019122
UniProt	P51670	P51670
RefSeq (mRNA)	NM_011338	NM_011338
RefSeq (protein)	NP_035468.1	NP_035468.1
Location (UCSC)	n/a	Chr 11: 83.57 – 83.58 Mb
PubMed search	[1]	[2]
Wikidata

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Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family. It is also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18, that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1.^[3] CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption.^[4] CCL9 is constitutively expressed in macrophages and myeloid cells.^[5][6] The gene for CCL9 is located on chromosome 11 in mice.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). "CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells". J Immunol. 171 (6): 2797–803. doi:10.4049/jimmunol.171.6.2797. PMID 12960300.
4. Lean J, Murphy C, Fuller K, Chambers T (2002). "CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts". J Cell Biochem. 87 (4): 386–93. doi:10.1002/jcb.10319. PMID 12397598.
5. Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). "A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors". J Immunol. 155 (5): 2661–7. PMID 7650394.
6. Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). "Molecular cloning and functional characterization of a novel member of the C-C chemokine family". J Immunol. 155 (11): 5352–8. PMID 7594550.