Lysine carboxypeptidase

Lysine carboxypeptidase
Identifiers
EC number 3.4.17.3
CAS number 9013-89-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lysine carboxypeptidase (EC 3.4.17.3, carboxypeptidase N, arginine carboxypeptidase, kininase I, anaphylatoxin inactivator, plasma carboxypeptidase B, creatine kinase conversion factor, bradykinase, kininase Ia, hippuryllysine hydrolase, bradykinin-decomposing enzyme, protaminase, CPase N, creatinine kinase convertase, peptidyl-L-lysine(-L-arginine) hydrolase, CPN) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of a C-terminal basic amino acid, preferentially lysine

This is a zinc enzyme found in plasma. It inactivates bradykinin and anaphylatoxins.

References

  1. Plummer, T.H. Jr.; Erdös, E.G. (1981). "Human plasma carboxypeptidase N". Methods Enzymol. 80: 442–449. doi:10.1016/s0076-6879(81)80038-9. PMID 7341915.
  2. Levin, Y.; Skidgel, R.A.; Erdös, E.G. (1982). "Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I)". Proc. Natl. Acad. Sci. USA. 79: 4618–4622. doi:10.1073/pnas.79.15.4618. PMID 6750606.
  3. Skidgel, R.A. (1988). "Basic carboxypeptidases: regulators of peptide hormone activity". Trends Pharmacol. Sci. 9: 301–303. doi:10.1016/0165-6147(88)90015-6. PMID 3074547.
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