Dextromethadone

Dextromethadone
Names
IUPAC name
(6S)-6-(Dimethylamino)-4,4-diphenylheptan-3-one
Other names
d-Methadone; 6S-Methadone; (+)-Methadone
Identifiers
5653-80-5
3D model (Jmol) Interactive image
ChemSpider 559067
ECHA InfoCard 100.164.915
PubChem 643985
Properties
C21H27NO
Molar mass 309.45 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Dextromethadone is an antitussive opioid.[1] It is the (S)-enantiomer of methadone.

There is now an asymmetric synthesis[2] available to prepare both dextromethadone [S-(+)-methadone] and levomethadone [R-(−)-methadone].[3]

See also

References

  1. Rasch, M (1957). "Dextromethadone and its antitussive effect". Nordisk medicin. 57 (17): 629–31. PMID 13441112.
  2. Hull JD, Scheinmann F, Turner NJ (March 2003). "Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations". Tetrahedron: Asymmetry. 14 (5): 567–576. doi:10.1016/S0957-4166(03)00019-3.
  3. US patent 6143933


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