Dimenoxadol

Dimenoxadol

Clinical data
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited) CA: Schedule I DE: Anlage I (Controlled) US: Schedule I UN: Psychotropic Schedule I
Identifiers
IUPAC name 2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate
Synonyms	Dimenoxadol, Estocin
CAS Number	509-78-4
PubChem (CID)	17036
DrugBank	DB01461
ChemSpider	16137
UNII	4D65PBX0VK
ChEMBL	CHEMBL2104309
Chemical and physical data
Formula	C20H25NO3
Molar mass	327.42 g/mol
3D model (Jmol)	Interactive image
SMILES Cl.CCOC(C(=O)OCCN(C)C)(c1ccccc1)c1ccccc1
InChI InChI=1S/C20H25NO3/c1-4-24-20(17-11-7-5-8-12-17,18-13-9-6-10-14-18)19(22)23-16-15-21(2)3/h5-14H,4,15-16H2,1-3H3 Key:RHUWRJWFHUKVED-UHFFFAOYSA-N
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Dimenoxadol (INN) (brand name Estocin (in Russia)), or dimenoxadole (BAN), is an opioid analgesic which is a benzilic acid derivative, closely related to benactyzine (an anticholinergic). Further, the structure is similar to methadone and related compounds like dextropropoxyphene.

It was invented in Germany in the 1950s,^[1] and produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.^[2][3][4]

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9617 and a 2013 annual aggregrate manufacturing quota of zero.

References

1. GB 716700, Boehringer, A et al., "A new and improved analgesic and process for its production", published 10/13/1954 
2. Gorbatova, E. N. (1967). "The pharmacology of estocin, an new analgesic". Stomatologiia. 46 (2): 22–25. PMID 5232927.
3. Kingisepp, G. A.; Kurvits, K.; Nurmand, L. B. (1969). "Pharmacology of dimethylaminoethyl ester of diphenylethoxyacetic acid hydrochloride--estocin". Farmakologiia i toksikologiia. 32 (6): 710–712. PMID 5381602.
4. Liberman, S. S. (1968). "Analgesic action of estocin (dimethylaminoethyl ester hydrochloride of alpha, alpha-diphenylethoxyacetic acid)". Farmakologiia i toksikologiia. 31 (6): 668–671. PMID 5729519.