eIF2B

eIF2B is a protein found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2, which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation.^[1]

Human genes which encode eIF-2B proteins include:

EIF2B1 – alpha subunit (26kDa)
EIF2B2 – beta subunit (39kDa)
EIF2B3 – gamma subunit (58kDa)
EIF2B4 – delta subunit (67kDa)
EIF2B5 – epsilon subunit (82kDa)

GTP-binding protein regulators

GTPase activating protein

Monomeric	Chimerin CHN1 CHN2 RasGAP NF1 IQGAP Tuberous sclerosis protein TSC1 TSC2

Heterotrimeric	Regulator of G protein signalling: RGS1 RGS2 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS21

Guanine nucleotide exchange factor

EIF2B Son of Sevenless Ras-GRF1

FGD	FGD1 FGD2 FGD3 FGD4

ALS2 SIL1 IQSEC2

Other

Guanosine nucleotide dissociation inhibitors

↑ "eIF2B, a mediator of general and gene-specific translational control.". Biochem Soc Trans. 33 (Pt 6): 1487–92. Dec 2005. doi:10.1042/BST20051487. PMID 16246152.

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