Estrogen-dependent condition

An estrogen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of estrogenic activity in the body.

Known estrogen-dependent conditions include mastodynia (breast pain/tenderness),^[1][2] breast fibroids,^[3] mammoplasia, macromastia (breast hypertrophy),^[4][5] gynecomastia,^[6] breast cancer,^[7] precocious puberty in girls,^[8] melasma,^[9] menorrhagia,^[10][11] endometriosis,^[12] endometrial hyperplasia,^[13] adenomyosis,^[13] uterine fibroids,^[7] uterine cancers (e.g., endometrial cancer),^[7] ovarian cancer,^[14] and hyperestrogenism in males such as in certain conditions like cirrhosis and Klinefelter's syndrome.^[15]

Such conditions may be treated with drugs with antiestrogen actions, including selective estrogen receptor modulators (SERMs) such as tamoxifen and clomifene, estrogen receptor antagonists such as fulvestrant, aromatase inhibitors such as anastrozole and exemestane,^[7] gonadotropin-releasing hormone (GnRH) analogues such as leuprolide and cetrorelix, and/or other antigonadotropins such as danazol, gestrinone, megestrol acetate, and medroxyprogesterone acetate.^[16][17]

See also

• Androgen-dependent condition
• Estrogen insensitivity syndrome

References

1. CURRENT OBSTETRICS and GYNECOLOGY by MUKHERJEE. Jaypee Brothers Publishers. 2007. pp. 347–. ISBN 978-81-8061-996-0.
2. Leonard J. Deftos (1 January 1998). Clinical Essentials of Calcium and Skeletal Disorders. Professional Communications. pp. 226–. ISBN 978-1-884735-39-4.
3. Linda Laucella (1 September 2002). The Hormone Decision. Contemporary Books. ISBN 978-0-07-141615-3.
4. Maria Siemionow; Marita Eisenmann-Klein (13 January 2010). Plastic and Reconstructive Surgery. Springer Science & Business Media. pp. 423–. ISBN 978-1-84882-513-0.
5. Merril D. Smith (8 September 2014). Cultural Encyclopedia of the Breast. Rowman & Littlefield Publishers. pp. 73–. ISBN 978-0-7591-2332-8.
6. Vasan; R.S. (1 January 1998). Textbook of Medicine. Orient Blackswan. pp. 1113–. ISBN 978-81-250-1266-5.
7. Edward J. Parish; W. David Nes (14 January 1997). Biochemistry and Function of Sterols. CRC Press. pp. 26–27. ISBN 978-0-8493-7674-0.
8. Michael Crocetti; Michael A. Barone; Frank A. Oski (2004). Oski's Essential Pediatrics. Lippincott Williams & Wilkins. pp. 564–. ISBN 978-0-7817-3770-8.
9. W. Steven Pray (2006). Nonprescription Product Therapeutics. Lippincott Williams & Wilkins. pp. 639–. ISBN 978-0-7817-3498-1.
10. Sharon L. Lewis; Shannon Ruff Dirksen; Margaret M. Heitkemper; Linda Bucher (2 December 2013). Medical-Surgical Nursing: Assessment and Management of Clinical Problems, Single Volume. Elsevier Health Sciences. pp. 1281–. ISBN 978-0-323-08678-3.
11. Guy I. Benrubi (28 March 2012). Handbook of Obstetric and Gynecologic Emergencies. Lippincott Williams & Wilkins. pp. 287–. ISBN 978-1-4511-4797-1.
12. Togas Tulandi; David Redwine (9 December 2003). Endometriosis: Advances and Controversies. CRC Press. pp. 125–. ISBN 978-0-8247-5864-6.
13. Reed Dunnick; Carl M. Sandler; Jeffrey H. Newhouse (15 October 2012). Textbook of Uroradiology. Lippincott Williams & Wilkins. pp. 377–378. ISBN 978-1-4511-0916-0.
14. Aurel Lupulescu (24 October 1990). Hormones and Vitamins in Cancer Treatment. CRC Press. pp. 33–. ISBN 978-0-8493-5973-6.
15. Eugene A. DeFelice (1 May 2002). Breast Cancer: Web Resource Guide for Consumers, Healthcare Providers, Patients, and Physicians. iUniverse. pp. 65–. ISBN 978-0-595-22651-1.
16. Bruce A. Chabner; Dan L. Longo (8 November 2010). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 651–673. ISBN 978-1-60547-431-1.
17. Debmalya Barh (13 October 2014). Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy. Springer. pp. 488–. ISBN 978-81-322-0843-3.