Fc receptor-like molecule

Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number of species, including humans and mice. They are preferentially expressed by B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. Their function is unknown.^[1]

It has been indicated that FCRLs may be a unique marker for immune cells in the brain called microglia, compared to other CNS cells and peripheral immune cells.^[2]

Members

• FCRL1
• FCRL2
• FCRL3
• FCRL4
• FCRL5
• FCRL6
• FCRLA. FCRLA associates with IgM, IgG and IgA.^[3]
• FCRLB

See also

• Fc receptor

References

1. Davis, Randall S. (2007). "Fc Receptor-Like Molecules". Annual Review of Immunology. 25: 525–60. doi:10.1146/annurev.immunol.25.022106.141541. PMID 17201682.
2. Butovsky, Oleg; Jedrychowski, Mark P; Moore, Craig S; Cialic, Ron; Lanser, Amanda J; Gabriely, Galina; Koeglsperger, Thomas; Dake, Ben; Wu, Pauline M; Doykan, Camille E; Fanek, Zain; Liu, LiPing; Chen, Zhuoxun; Rothstein, Jeffrey D; Ransohoff, Richard M; Gygi, Steven P; Antel, Jack P; Weiner, Howard L (2014). "Identification of a unique TGF-β–dependent molecular and functional signature in microglia". Nature Neuroscience. 17 (1): 131–43. doi:10.1038/nn.3599. PMC 4066672. PMID 24316888.
3. Santiago, T.; Kulemzin, S. V.; Reshetnikova, E. S.; Chikaev, N. A.; Volkova, O. Y.; Mechetina, L. V.; Zhao, M.; Davis, R. S.; Taranin, A. V.; Najakshin, A. M.; Hendershot, L. M.; Burrows, P. D. (2011). "FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA". International Immunology. 23 (1): 43–53. doi:10.1093/intimm/dxq456. PMC 3003704. PMID 21149418.

Further reading

• Maltais, Lois J; Lovering, Ruth C; Taranin, Alexander V; Colonna, Marco; Ravetch, Jeffrey V; Dalla-Favera, Riccardo; Burrows, Peter D; Cooper, Max D; Davis, Randall S (2006). "New nomenclature for Fc receptor–like molecules". Nature Immunology. 7 (5): 431–2. doi:10.1038/ni0506-431. PMID 16622424.
• Ehrhardt, Götz R. A.; Cooper, Max D. (2011). "Immunoregulatory Roles for Fc Receptor-Like Molecules". In Ahmed, Rafi; Honjo, Tasuku. Negative Co-Receptors and Ligands. Current Topics in Microbiology and Immunology. pp. 89–104. doi:10.1007/82_2010_88. ISBN 978-3-642-19544-0. PMID 20680805.
• Aranha, Clara; Bordekar, Arvind; Shahani, Savitri (1998). "Isolation and purification of an early pregnancy factor-like molecule from culture supernatants obtained from lymphocytes of pregnant women: II. Identification of the molecule as a Fc-receptor-like molecule: a preliminary report". Journal of Assisted Reproduction and Genetics. 15 (10): 619–24. doi:10.1023/A:1020389512677. PMC 3454852. PMID 9866072.
• Wu, Hua; Yang, Li-Hua; Zuo, Ji; Liang, Ya-Ling; Li, Pei-Qiang; Liu, Wen; Xie, Xiao-Dong (2010). "Fc receptor–like 3 gene polymorphisms confer susceptibility to rheumatoid arthritis in a Chinese population". Human Immunology. 71 (12): 1203–8. doi:10.1016/j.humimm.2010.08.002. PMID 20732364.
• Ehrhardt, Götz R. A.; Leu, Chuen-Miin; Zhang, Shuangyin; Aksu, Güzide; Jackson, Tanisha; Haga, Chris; Hsu, Joyce T.; Schreeder, Daniel M.; Davis, Randall S.; Cooper, Max D. (2007). "Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function". In Gupta, Sudhir; Alt, Frederick; Cooper, Max; Melchers, Fritz; Rajewsky, Klaus. Mechanisms of Lymphocyte Activation and Immune Regulation XI. Advances in Experimental Medicine and Biology. pp. 155–62. doi:10.1007/0-387-46530-8_14. ISBN 978-0-387-46527-2. PMID 17338184.
• Rozsnyay, Z; Sármay, G; Szabó, I; Medgyesi, G; Gorini, G; Gergely, J (1990). "Fine specificity of a rabbit antibody interacting with human IgG Fc receptor-like molecules". Immunology Letters. 25 (4): 303–11. PMID 2147423.