GBR-13098

GBR-13098

Names
IUPAC name 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-[3-(4-fluorophenyl)propyl]piperazine
Identifiers
3D model (Jmol)	Interactive image
ChemSpider	117130
PubChem	132673
InChI InChI=1S/C28H31F3N2O/c29-25-9-3-22(4-10-25)2-1-15-32-16-18-33(19-17-32)20-21-34-28(23-5-11-26(30)12-6-23)24-7-13-27(31)14-8-24/h3-14,28H,1-2,15-21H2 Key: OEZGWIMXRXRLRR-UHFFFAOYSA-N InChI=1/C28H31F3N2O/c29-25-9-3-22(4-10-25)2-1-15-32-16-18-33(19-17-32)20-21-34-28(23-5-11-26(30)12-6-23)24-7-13-27(31)14-8-24/h3-14,28H,1-2,15-21H2 Key: OEZGWIMXRXRLRR-UHFFFAOYAF
SMILES C1CN(CCN1CCCC2=CC=C(C=C2)F)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Properties
Chemical formula	C28H31F3N2O
Molar mass	468.56 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.^[1]

Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.^[2]

See also

• Vanoxerine
• GBR-12783
• GBR-12935
• GBR-13069
• DBL-583

References

1. Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies.". Naunyn Schmiedebergs Arch Pharmacol. 334 (4): 383–7. PMID 2950328.
2. Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791.