GFRA1

GFRA1
Identifiers
Aliases	GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha 1
External IDs	MGI: 1100842 HomoloGene: 3855 GeneCards: GFRA1
Gene ontology Molecular function • receptor activity • receptor binding • glial cell-derived neurotrophic factor receptor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • anchored component of membrane • extracellular exosome • membrane • extrinsic component of membrane • intracellular • plasma membrane Biological process • cell surface receptor signaling pathway • nervous system development • positive regulation of GTPase activity • MAPK cascade • glial cell-derived neurotrophic factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2674	14585
Ensembl	ENSG00000151892	ENSMUSG00000025089
UniProt	P56159	P97785
RefSeq (mRNA)	NM_001145453 NM_005264 NM_145793	NM_001285457 NM_010279
RefSeq (protein)	NP_001138925.1 NP_005255.1 NP_665736.1	NP_001272386.1 NP_034409.1
Location (UCSC)	Chr 10: 116.06 – 116.27 Mb	Chr 19: 58.24 – 58.46 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.^[3][4]

Function

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[5]

Interactions

GDNF family receptor alpha 1 has been shown to interact with GDNF^[6][7] and RET proto-oncogene.^[7][8]

See also

• GFRα

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998). "Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization". Cytogenetics and Cell Genetics. 78 (3-4): 289–90. doi:10.1159/000134674. PMID 9465905.
4. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (Mar 1998). "Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility". Genomics. 48 (3): 354–62. doi:10.1006/geno.1997.5191. PMID 9545641.
5. "Entrez Gene: GFRA1 GDNF family receptor alpha 1".
6. Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
7. Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE (Sep 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". The Journal of Biological Chemistry. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
8. Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (Jun 1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.

Further reading

• Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A (Jul 1996). "Characterization of a multicomponent receptor for GDNF". Nature. 382 (6586): 80–3. doi:10.1038/382080a0. PMID 8657309.
• Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM (Jun 1996). "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF". Cell. 85 (7): 1113–24. doi:10.1016/S0092-8674(00)81311-2. PMID 8674117.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi FM, Chiappetta G, Consales C, Improta S, Zagonel V, Aldinucci D, Agosti V, Santoro M, Vecchio G, Pinto A, Grieco M (Apr 1997). "Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment". Blood. 89 (8): 2925–37. PMID 9108413.
• Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (Jun 1997). "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6238–43. doi:10.1073/pnas.94.12.6238. PMC 21033. PMID 9177201.
• Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J (May 1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret". Neuron. 18 (5): 793–802. doi:10.1016/S0896-6273(00)80318-9. PMID 9182803.
• Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (Jun 1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.
• Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
• Eng C, Myers SM, Kogon MD, Sanicola M, Hession C, Cate RL, Mulligan LM (Feb 1998). "Genomic structure and chromosomal localization of the human GDNFR-alpha gene". Oncogene. 16 (5): 597–601. doi:10.1038/sj.onc.1201573. PMID 9482105.
• Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF (Apr 1998). "Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux". Human Genetics. 102 (4): 474–8. doi:10.1007/s004390050724. PMID 9600247.
• Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A (Jul 1998). "GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney". Neuron. 21 (1): 53–62. doi:10.1016/S0896-6273(00)80514-0. PMC 2710137. PMID 9697851.
• Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM (Sep 1998). "GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin". Current Biology. 8 (18): 1019–22. doi:10.1016/S0960-9822(07)00422-8. PMID 9740802.
• Tansey MG, Baloh RH, Milbrandt J, Johnson EM (Mar 2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival". Neuron. 25 (3): 611–23. doi:10.1016/S0896-6273(00)81064-8. PMID 10774729.
• Hase A, Suzuki H, Arahata K, Akazawa C (Jul 1999). "Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves". Neuroscience Letters. 269 (1): 55–7. doi:10.1016/S0304-3940(99)00419-X. PMID 10821644.
• Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE (Sep 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". The Journal of Biological Chemistry. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
• Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibáñez CF (Jan 2001). "Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts". Neuron. 29 (1): 171–84. doi:10.1016/S0896-6273(01)00188-X. PMID 11182089.
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Japón MA, Urbano AG, Sáez C, Segura DI, Cerro AL, Diéguez C, Alvarez CV (Apr 2002). "Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors". The Journal of Clinical Endocrinology and Metabolism. 87 (4): 1879–84. doi:10.1210/jc.87.4.1879. PMID 11932334.