GRK4

GRK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YHJ
Identifiers
Aliases	GRK4, GPRK2L, GPRK4, GRK4a, IT11, G protein-coupled receptor kinase 4
External IDs	MGI: 95801 HomoloGene: 23158 GeneCards: GRK4
Targeted by Drug
balanol[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • G-protein coupled receptor kinase activity • kinase activity • protein serine/threonine kinase activity • ATP binding • rhodopsin kinase activity Cellular component • cytoplasm • cytosol • neuronal cell body • dendrite • cell cortex • photoreceptor disc membrane Biological process • G-protein coupled receptor internalization • regulation of G-protein coupled receptor protein signaling pathway • phosphorylation • regulation of rhodopsin mediated signaling pathway • receptor internalization • protein phosphorylation • desensitization of G-protein coupled receptor protein signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2868	14772
Ensembl	ENSG00000125388	ENSMUSG00000052783
UniProt	P32298	O70291
RefSeq (mRNA)	NM_001004056 NM_001004057 NM_005307 NM_182982	NM_001080743 NM_019497
RefSeq (protein)	NP_001004056.1 NP_001004057.1 NP_005298.2 NP_892027.2	NP_001074212.1 NP_062370.2
Location (UCSC)	Chr 4: 2.96 – 3.04 Mb	Chr 5: 34.66 – 34.76 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.^[4][5]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.^[5]

References

1. "Drugs that physically interact with G protein-coupled receptor kinase 4 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ, et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet. 1 (9): 697–703. doi:10.1093/hmg/1.9.697. PMID 1338872.
5. "Entrez Gene: GRK4 G protein-coupled receptor kinase 4".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Sallese M, Lombardi MS, De Blasi A (1994). "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning". Biochem. Biophys. Res. Commun. 199 (2): 848–54. doi:10.1006/bbrc.1994.1306. PMID 8135832.
• Premont RT, Macrae AD, Stoffel RH, et al. (1996). "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants". J. Biol. Chem. 271 (11): 6403–10. doi:10.1074/jbc.271.11.6403. PMID 8626439.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sallese M, Mariggiò S, Collodel G, et al. (1997). "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells". J. Biol. Chem. 272 (15): 10188–95. doi:10.1074/jbc.272.15.10188. PMID 9092566.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lazari MF, Liu X, Nakamura K, et al. (1999). "Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor". Mol. Endocrinol. 13 (6): 866–78. doi:10.1210/me.13.6.866. PMID 10379886.
• Blaukat A, Pizard A, Breit A, et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
• Watanabe H, Xu J, Bengra C, et al. (2003). "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4". Kidney Int. 62 (3): 790–8. doi:10.1046/j.1523-1755.2002.00525.x. PMID 12164861.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Perroy J, Adam L, Qanbar R, et al. (2003). "Phosphorylation-independent desensitization of GABAB receptor by GRK4". EMBO J. 22 (15): 3816–24. doi:10.1093/emboj/cdg383. PMC 169056. PMID 12881416.
• Speirs HJ, Katyk K, Kumar NN, et al. (2004). "Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension". J. Hypertens. 22 (5): 931–6. doi:10.1097/00004872-200405000-00014. PMID 15097232.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rankin ML, Marinec PS, Cabrera DM, et al. (2006). "The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4". Mol. Pharmacol. 69 (3): 759–69. doi:10.1124/mol.105.019901. PMID 16338988.
• Zhu H, Lu Y, Wang X, et al. (2006). "The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins". Am. J. Hypertens. 19 (1): 61–6. doi:10.1016/j.amjhyper.2005.07.007. PMID 16461192.
• Zhu H, Lu Y, Wang X, et al. (2006). "The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents". Pediatr. Res. 60 (4): 440–2. doi:10.1203/01.pdr.0000238250.64591.44. PMID 16940246.
• Wang Y, Li B, Zhao W, et al. (2006). "Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese". Ann. Hum. Genet. 70 (Pt 6): 778–83. doi:10.1111/j.1469-1809.2006.00278.x. PMID 17044852.
• Wang Z, Armando I, Asico LD, et al. (2007). "The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2083–92. doi:10.1152/ajpheart.00944.2006. PMID 17259440.