PRKCG

PRKCG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E73, 2UZP
Identifiers
Aliases	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma
External IDs	MGI: 97597 HomoloGene: 20602 GeneCards: PRKCG
Targeted by Drug
ingenol mebutate, balanol, enzastaurin, ruboxistaurin[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • zinc ion binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • ATP binding • calcium-dependent protein kinase C activity Cellular component • cytoplasm • synaptic membrane • cytosol • cell projection • membrane • cell-cell junction • plasma membrane • synapse • intracellular • cell junction • dendrite • perinuclear region of cytoplasm • neuron projection • nucleus Biological process • negative regulation of neuron apoptotic process • intracellular signal transduction • phosphorylation • negative regulation of protein catabolic process • rhythmic process • regulation of response to food • response to stress • platelet activation • chemosensory behavior • negative regulation of protein ubiquitination • protein phosphorylation • response to morphine • positive regulation of mismatch repair • response to pain • regulation of circadian rhythm • peptidyl-serine phosphorylation • learning or memory • protein autophosphorylation • negative regulation of proteasomal protein catabolic process • regulation of phagocytosis • innervation • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5582	18752
Ensembl	ENSG00000126583	n/a
UniProt	P05129	P63318
RefSeq (mRNA)	NM_002739 NM_001316329	NM_001291434 NM_011102
RefSeq (protein)	NP_002730.1 NP_001303258.1	NP_035232.1
Location (UCSC)	Chr 19: 53.88 – 53.91 Mb	Chr 7: 3.29 – 3.33 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.^[4][5]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).^[6]

Interactions

PRKCG has been shown to interact with GRIA4.^[7]

See also

• Protein kinase C

References

1. "Drugs that physically interact with Protein kinase C gamma type view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
5. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. doi:10.1126/science.3755548. PMID 3755548.
6. "Entrez Gene: PRKCG protein kinase C, gamma".
7. Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. United States. 278 (8): 6307–13. doi:10.1074/jbc.M205587200. ISSN 0021-9258. PMID 12471040.

External links

• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14

Further reading

• Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation.". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
• Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.". Chem. Phys. Lipids. 116 (1–2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536.
• Saito N, Shirai Y (2003). "Protein kinase C gamma (PKC gamma): function of neuron specific isotype". J. Biochem. 132 (5): 683–7. doi:10.1093/oxfordjournals.jbchem.a003274. PMID 12417016.