HLA-Cw4
HLA-Cw4 (MHC Class I, C cell surface antigen) | |||
HLA-Cw4 | |||
- | |||
Protein | transmembrane receptor/ligand | ||
Structure | αβ heterodimer | ||
Subunits | HLA-Cw*04--, β2-microglobulin | ||
Older names | "-" | ||
- | |||
subtype | allele | Available structures | |
Cw4 | *0401 | ||
rare alleles | |||
Cw403 | *0403 | ||
Alleles link-out to IMGT/HLA database at EBI |
HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.
Serotype
Cw*04 | Cw4 | Cw403 | Cw6 | Sample |
allele | % | % | % | size (N) |
*0401 | 98 | 0 | 0 | 736 |
*0403 | 37 | 5 | 17 | 25 |
Alleles
Study population |
Freq. (in %)[3] |
---|---|
Mexico Mixe Oaxaca | 37.8 |
Mexico Mixtec Oaxaca | 37.3 |
USA N. Mexico Canoncito N… | 31.7 |
Mexico Zaptotec Oaxaca | 30.6 |
Iran Baloch | 28.6 |
Australia Indig. Cape Yor… | 27.5 |
Australia Indig.Yuendumu | 26.8 |
Australia Indig. Groote E… | 25.3 |
Lebanon | 24.3 |
Israel Arab Druse | 22.5 |
Georgia Tibilisi Kurds | 22.4 |
Brazil Terena | 22.3 |
Georgia Tibilisi Georgian… | 22.0 |
India Tamil Nadu Nadar | 21.3 |
Mali Bandiagara | 21.3 |
Taiwan Ami | 20.9 |
Papua New Guinea Wanigela | 20.8 |
USA African Americans pop… | 19.6 |
Senegal Niokholo Mandenka | 19.5 |
Cameroon Beti | 18.7 |
Indig. Australian Kimberl… | 17.9 |
Papua New Guinea Wosera | 17.0 |
Italy North pop 1 | 16.7 |
New Caledonia | 16.7 |
Morocco Nador Metalsa (be… | 15.9 |
Portugal Centre pop 2 | 15.8 |
Cameroon Sawa | 15.4 |
India Mumbai Marathas | 15.4 |
Iran Tehran | 15.4 |
USA Hispanic | 15.0 |
PNG West Schrader Ranges | 14.8 |
Zimbabwe Harare Shona | 14.8 |
Swiss Geneva | 14.5 |
Zambia Lusaka | 14.4 |
Uganda Kampala | 14.1 |
Brazil | 13.7 |
Sudanese | 13.5 |
France West | 13.4 |
Tibetan | 13.3 |
Finland | 13.3 |
Kenya Luo | 13.2 |
Cameroon Bamileke | 13.0 |
Philippines Ivatan | 13.0 |
Kenya | 12.9 |
Singapore Riau Malay | 12.2 |
India North Delhi | 11.7 |
Tunisia | 11.6 |
Kenya Nandi | 11.5 |
Russia Tuva pop 2 | 11.5 |
Taiwan Bunun | 11.4 |
USA Caucasian pop2 | 11.1 |
India West Coast Parsis | 11.0 |
China Qinghai Hui | 10.9 |
Czech Republic | 10.8 |
India New Delhi | 10.7 |
Spain Eastern Andalusia | 10.4 |
UK Caucasians | 10.1 |
Cameroon Pygmy Baka | 10.0 |
China Beijing | 10.0 |
Jordan Amman | 10.0 |
Singapore Javanese | 10.0 |
Papua New Guinea Madang | 9.5 |
Saudi Arabia Guraiat and … | 9.5 |
Australia New South Wales | 9.4 |
USA Alaska Yupik Natives | 9.3 |
Bulgaria Gipsy | 9.1 |
Mex. Chihuahua Tarahumara | 9.1 |
German Essen | 9.0 |
France South East | 8.9 |
Taiwan Paiwan | 8.8 |
China Inner Mongolia | 8.3 |
Ireland Northern | 8.3 |
Venezuela Perija Yucpa | 8.3 |
South Korea (1) | 8.2 |
China North Han | 7.6 |
USA South Dakota Lakota S… | 7.4 |
Taiwan Atayal | 7.1 |
India West Bhils | 7.0 |
PNG Karimui Plateau | 6.9 |
Taiwan Siraya | 6.9 |
Taiwan Thao | 6.7 |
Japan (5) | 6.5 |
Thailand | 6.0 |
China Guangzhou | 5.6 |
USA Asian | 5.6 |
Ireland South | 5.4 |
PNG Eastern Highlands Gor… | 4.7 |
Japan Central | 4.6 |
Spain Eastern Andalusia G… | 4.5 |
China South Han | 4.4 |
South Africa Natal Tamil | 4.2 |
American Samoa | 4.0 |
Taiwan Saisiat | 3.9 |
Papua New Guinea New Brit… | 3.6 |
Taiwan Minnan pop 1 | 3.4 |
USA Hawaii Okinawa | 3.3 |
China Guangdong Meizhou H… | 3.0 |
India Khandesh Pawra | 3.0 |
Taiwan Puyuma | 3.0 |
Allele frequencies presented, only |
Study population |
Freq. (in %)[3] |
---|---|
PNG West Schrader Ranges | 45.9 |
Taiwan Tao | 40.0 |
PMG Eastern Highlands Gor… | 34.9 |
PNG Madang | 25.0 |
PNG Wanigela | 16.0 |
Australia Indig. Cape Yor… | 15.7 |
Australia Indig. Yuendumu | 15.1 |
Australia Indig. Groote E… | 12.3 |
Taiwan Puyuma | 12.0 |
PNG Karimui Plateau | 11.9 |
Taiwan Pazeh | 11.8 |
Taiwan Thao | 11.7 |
New Caledonia | 11.1 |
Singapore Riau Malay | 9.8 |
PNG New Britain Rabaul | 8.9 |
PNG Wosera | 8.0 |
Singapore Javanese | 7.0 |
Taiwan Rukai | 7.0 |
Taiwan Bunun | 6.4 |
American Samoa | 6.0 |
Thailand | 5.3 |
Philippines Ivatan | 5.0 |
Taiwan Siraya | 4.9 |
Taiwan Tsou | 4.9 |
Australia Indig. Kimberly | 3.6 |
Taiwan Atayal | 3.3 |
South Africa Natal Tamil | 3.1 |
Taiwan Ami | 2.6 |
China South Han | 2.1 |
USA Asian | 2.0 |
Taiwan Hakka | 1.8 |
China Qinghai Hui | 1.4 |
Iran Tehran | 1.3 |
China Guangdong Meizhou H… | 1.0 |
China Inner Mongolia | 1.0 |
India West Coast Parsis | 1.0 |
Taiwan Minnan pop 1 | 1.0 |
Taiwan Paiwan | 1.0 |
India New Delhi | 0.9 |
Russia Tuva | 0.9 |
China Tibetan | 0.6 |
Allele frequencies presented, only |
References
- ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- 1 2 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
This article is issued from Wikipedia - version of the 7/1/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.