HLA-DOA

HLA-DOA
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, HLA-DOA, major histocompatibility complex, class II, DO alpha
External IDs MGI: 95924 HomoloGene: 1601 GeneCards: HLA-DOA
Genetically Related Diseases
periodontitis[1]
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

3111

15001

Ensembl

n/a

ENSMUSG00000024334

UniProt

P06340

n/a

RefSeq (mRNA)

NM_002119

NM_008206

RefSeq (protein)

NP_002110.1

n/a

Location (UCSC) Chr 6: 33 – 33.01 Mb Chr 17: 34.09 – 34.1 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[4][5]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[5]

References

Further reading


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