Hippocalcin

HPCA
Identifiers
Aliases	HPCA, BDR2, DYT2, hippocalcin
External IDs	OMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA
Gene ontology Molecular function • calcium ion binding • metal ion binding • kinase binding • actin binding Cellular component • perikaryon • dendrite membrane • neuronal cell body membrane • axon • dendritic spine head • dendrite cytoplasm Biological process • positive regulation of adenylate cyclase activity • response to organic cyclic compound • cellular response to monosodium glutamate • negative regulation of guanylate cyclase activity • positive regulation of phospholipase activity • activation of phospholipase D activity • brain development • retina development in camera-type eye • response to ketamine • response to L-glutamate • inner ear development • response to Aroclor 1254 • calcium-mediated signaling • positive regulation of protein targeting to membrane • cellular response to electrical stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3208	15444
Ensembl	ENSG00000121905	ENSMUSG00000028785
UniProt	P84074	P84075
RefSeq (mRNA)	NM_002143	NM_001130419 NM_010471 NM_001286081 NM_001286083
RefSeq (protein)	NP_002134.2	NP_001123891.1 NP_001273010.1 NP_001273012.1 NP_034601.1
Location (UCSC)	Chr 1: 32.89 – 32.9 Mb	Chr 4: 129.11 – 129.12 Mb
PubMed search	[1]	[2]
Wikidata

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Hippocalcin is a protein that in humans is encoded by the HPCA gene.^[3][4]

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.^[5][6] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.^[7]

Processes

Hippocalcin takes part in the following processes:

• Activation of PLD1 and PLD2 expression
• Inhibition of apoptosis
• MAP kinase signalling
• Involved in long term depression in hippocampal neuron
• Required for normal spatial learning

Interactions

Hippocalcin interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)
• Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
• The b2 adaptin of the AP2 complex
• Calcium-dependent activator protein for secretion (CADPS)

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID 8166736.
4. Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene. 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID 9931466.
5. Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
6. Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
7. O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC 2173692. PMID 14638856.

Further reading

• Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172.
• Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. Neurol. Sci. 281 (1–2): 51–4. doi:10.1016/j.jns.2009.02.375. PMID 19332348.
• Kobayashi M, Takamatsu K, Saitoh S, et al. (1992). "Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus". Biochem. Biophys. Res. Commun. 189 (1): 511–7. doi:10.1016/0006-291X(92)91587-G. PMID 1280427.
• Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
• Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. PMID 8360179.
• Rudinskiy N, Kaneko YA, Beesen AA, et al. (2009). "Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons". J. Neurochem. 111 (2): 460–72. doi:10.1111/j.1471-4159.2009.06344.x. PMID 19686238.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC 313967. PMID 10899114.
• Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.
• O'Callaghan DW, Haynes LP, Burgoyne RD (2005). "High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate". Biochem. J. 391 (Pt 2): 231–8. doi:10.1042/BJ20051001. PMC 1276920. PMID 16053445.
• O'Callaghan DW, Ivings L, Weiss JL, et al. (2002). "Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction". J. Biol. Chem. 277 (16): 14227–37. doi:10.1074/jbc.M111750200. PMID 11836243.
• Markova 0, Fitzgerald D, Stepanyuk A; et al. (2009). "Hippocalcin signaling via site-specific translocation in hippocampal neurons". Neurosci. Lett. 442 (2): 152–7. doi:10.1016/j.neulet.2008.06.089. PMC 2572729. PMID 18634855.

External links

• NCS proteins