Sarcalumenin
| SRL | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||
| Aliases | SRL, entrez:6345 | ||||||||||||||||
| External IDs | OMIM: 604992 MGI: 2146620 HomoloGene: 45500 GeneCards: SRL | ||||||||||||||||
| Genetically Related Diseases | |||||||||||||||||
| obesity[1] | |||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
| Entrez | |||||||||||||||||
| Ensembl | |||||||||||||||||
| UniProt | |||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 16: 4.19 – 4.24 Mb | Chr 16: 4.48 – 4.54 Mb | |||||||||||||||
| PubMed search | [2] | [3] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
Sarcalumenin is a protein that in humans is encoded by the SAR gene.[4][5]
Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.[6] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.[7] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.[6]
References
- ↑ "Diseases that are genetically associated with SRL view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Leberer E; Charuk JH; Green NM; MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 86 (16): 6047–51. doi:10.1073/pnas.86.16.6047. PMC 297772
. PMID 2762314. - ↑ Lanfranchi G; Muraro T; Caldara F; Pacchioni B; Pallavicini A; Pandolfo D; Toppo S; Trevisan S; Scarso S; Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Res. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
- 1 2 Jiao Q; Bai Y; Akaike T; Takeshima H; Ishikawa Y; Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". Am. J. Physiol. Heart Circ. Physiol. 297 (2): H576–82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.
- ↑ Yoshida M; Minamisawa S; Shimura M; Komazaki S; Kume H; Zhang M; Matsumura K; Nishi M; Saito M; Saeki Y; Ishikawa Y; Yanagisawa T; Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". J. Biol. Chem. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.
External links
- sarcalumenin at the US National Library of Medicine Medical Subject Headings (MeSH)
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