Methylhomatropine

Homatropine methyl bromide
Clinical data
ATC code A02BX03 (WHO)
Identifiers
CAS Number 80-49-9
PubChem (CID) 6646
DrugBank DB00725
ChemSpider 6394 YesY
UNII 68JRS2HC1C YesY
ChEMBL CHEMBL1200851
ECHA InfoCard 100.001.168
Chemical and physical data
Formula C17H24BrNO3
Molar mass 370.26 g/mol
3D model (Jmol) Interactive image
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Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics.[1] It is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose.[2]

Contraindications

References


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