Pentobarbital
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 | |
| Clinical data | |
|---|---|
| Trade names | Nembutal |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682416 |
| License data |
|
| Pregnancy category | |
| Routes of administration | By mouth, IV, IM, rectal; also intraperitoneal & intracardiac (for animal euthanasia) |
| ATC code | N05CA01 (WHO) QN51AA01 (WHO) |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 70–90% (oral); 90% (rectal) |
| Protein binding | 20–45% |
| Metabolism | Liver |
| Biological half-life | 15–48 hours |
| Excretion | Kidney |
| Identifiers | |
| |
| CAS Number |
76-74-4  |
| PubChem (CID) | 4737 |
| IUPHAR/BPS | 5480 |
| DrugBank |
DB00312 |
| ChemSpider |
4575 |
| UNII |
I4744080IR |
| KEGG |
D00499 |
| ChEBI |
CHEBI:7983 |
| ChEMBL |
CHEMBL448 |
| ECHA InfoCard | 100.000.895 |
| Chemical and physical data | |
| Formula | C11H18N2O3 |
| Molar mass | 226.27 |
| 3D model (Jmol) | Interactive image |
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| (verify) | |
Pentobarbital (US English) or pentobarbitone (UK English) is a short-acting barbiturate. Pentobarbital can occur as both a free acid and as salts of elements such as sodium and calcium. The free acid is only slightly soluble in water and ethanol.[1][2]
One brand name for this drug is Nembutal, coined by John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt—Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates).[3] Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck, and is the only injectable form of pentobarbital approved for sale in the United States.[4]
In high doses, pentobarbital causes death by respiratory arrest. In the United States, the drug has been used for executions of convicted criminals. Lundbeck (one of many manufacturers) does not permit its sale to prisons or corrections departments to carry out the death penalty.[5]
Uses
Medical
Typical applications for pentobarbital are sedative, hypnotic for short term, preanesthetic and control of convulsions in emergencies.[6]
It is also used as a veterinary anesthetic agent.[7]
Pentobarbital also has an application in reducing intracranial pressure in Reye's syndrome, traumatic brain injury and induction of coma in cerebral ischemia patients.[8] Pentobarbital-induced coma has been advocated in patients with acute liver failure refractory to mannitol.[9]
Euthanasia
Pentobarbital can induce death when used in high doses. It is used for euthanasia for humans as well as nonhumans. It is also used by itself, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.
In the Netherlands, the standard protocol for physician-assisted suicide is intravenously induced thiopental anesthesia, followed by bromide of alcuronium- or pancuronium-induced respiratory arrest. A concentrated oral solution of 100 mL containing 9 grams of pentobarbital sodium along with sugar syrup in a 20% ethanol solution is a standard solution used for self-administration by patient.[10]
The oral dosage of pentobarbital indicated for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January, 2016) is typically 10 g in liquid form.[11][12] This is considerably higher than the dose for the management of status epilepticus.[13]
Capital punishment
Pentobarbital has been used or considered as a substitute for other drugs traditionally used in the United States for execution when they are in short supply.[14] Such use however is illegal under Danish law, and when this was discovered, after public outcry in Danish media, Lundbeck, the owner of the drug, stopped selling it to US States that practice death penalty. US distributors of the drug are forbidden by the owner to sell it to any customers, such as several state authorities, that practice or participate in executions of humans.[15]
Texas began using pentobarbital for executing death row inmates by lethal injection on July 18, 2012.[16] The use of pentobarbital has been considered by several states, including Ohio, Arizona, Idaho and Washington; those states made the decision to switch following shortages of pancuronium bromide, a muscle relaxant previously used as one component in a three-drug cocktail.[17]
In October 2013, Missouri changed its protocols to allow for a compounded pentobarbital to be used in a lethal dose for executions.[18] On November 20, 2013, Joseph Paul Franklin was executed by the state of Missouri.[19] He was the first inmate executed in three years in the state and the first to die by a single dose of pentobarbital.[20]
Metabolism
Pentobarbital undergoes first-pass metabolism in the liver and possibly the intestines.[21]
Drug interactions
Administration of ethanol, benzodiazepines, opioids, antihistamines, other sedative-hypnotics, and other central nervous system depressants will cause possible additive effects.[8]
Chemistry
Pentobarbital is synthesized by methods analogous to that of amobarbital, the only difference being that the alkylation of α-ethylmalonic ester is carried out with 2-bromopentane (not 1-bromo-3-methylbutane) to give pentobarbital.[22][23][24]
References
- ↑ "Pentobarbital Compound summary (CID4737)". Pubchem. NCBI.
- ↑ "FR1972_08_25_17226" (PDF). Food and Drug Administration.
- ↑ Fosburgh LC (1997). "From this point in time: Some memories of my part in the history of anesthesia--John S. Lundy, MD". AANA Journal. 65 (4): 323–328. PMID 9281913.
- ↑ Jolly, David (1 Jul 2011). "Danish Company Blocks Sale of Drug for U.S. Executions". The New York Times. Retrieved 20 Nov 2013.
- ↑ "Ohio says it will switch to new drugs for executions". Reuters. Oct 28, 2013.
- ↑ "NEMBUTAL SODIUM (pentobarbital sodium) injection, solution". DailyMed, National Institutes of Health.
- ↑ "International". Drugs.com.
- 1 2 "Pentobarbital". Monograph. AHFS / Drugs.com.
- ↑ Stravitz RT, Kramer AH, Davern T, Shaikh AO, Caldwell SH, Mehta RL, Blei AT, Fontana RJ, McGuire BM, Rossaro L, Smith AD, Lee WM (2007). "Intensive care of patients with acute liver failure: Recommendations of the U.S. Acute Liver Failure Study Group". Critical Care Medicine. 35 (11): 2498–2508. doi:10.1097/01.CCM.0000287592.94554.5F. PMID 17901832.
- ↑ "Euthanica". Euthanesia Dossier (in Dutch). NRC Webpagina's.
- ↑ Jennifer Fass; Andrea Fass (2011). "Physician-assisted Suicide: Ongoing Challenges for Pharmacists". Am J Health Syst Pharm. 68 (9): 846–849. doi:10.2146/ajhp100333. PMID 21515870.
- ↑ Philip Nitschke; Fiona Stewart (2006). The Peaceful Pill Handbook. Exit International US Ltd. p. 137. ISBN 0978878809.
- ↑ Lexi-Comp Inc. (2010) Lexi-Comp Drug Information Handbook 19th North American Ed. Hudson, OH: Lexi-Comp Inc. ISBN 978-1-59195-278-7.
- ↑ "States urge feds to help import lethal injection drugs". CNN. May 21, 2012.
- ↑ "The Hidden Hand Squeezing Texas' Supply of Execution Drugs". Time. 7 August 2013.
- ↑ "Texas executes Yokamon Hearn with pentobarbitol". BBC News. 18 July 2012.
- ↑ "Texas executes Yokamon Hearn". Retrieved 20 July 2012.
- ↑ "Lethal injection: Secretive US states resort to untested drugs - BBC News". BBC News. Retrieved 2016-03-17.
- ↑ http://news.yahoo.com/missouri-executes-serial-killer-franklin-122636393.html
- ↑ http://www.christianpost.com/news/joseph-paul-franklin-executed-first-mo-inmate-killed-using-pentobarbital-109150/
- ↑ Knodell RG, Spector MH, Brooks DA, Keller FX, Kyner WT (1980). "Alterations in pentobarbital pharmacokinetics in response to parenteral and enteral alimentation in the rat". Gastroenterology. 79 (6): 1211–1216. PMID 6777235.
- ↑ Volwiler, E. H.; Tabern, D. L. (1930). "5,5-SUBSTITUTED BARBITURIC ACIDS". Journal of the American Chemical Society. 52 (4): 1676–1679. doi:10.1021/ja01367a061.
- ↑ German imperial patent, D.R.P. 293163 (1916), Bayer
- ↑ GB patent 650354, Wilde, B. E. & Balaban, I. E., "Improvements in the manufacture of substituted barbituric and thiobarbituric acids", issued 1951-02-21, assigned to Geigy