Hydrogenase (NAD+, ferredoxin)

Hydrogenase (NAD+, ferredoxin)
Identifiers
EC number 1.12.1.4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hydrogenase (NAD+, ferredoxin) (EC 1.12.1.4, bifurcating [FeFe] hydrogenase) is an enzyme with systematic name hydrogen:NAD+, ferredoxin oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2 H2 + NAD+ + 2 oxidized ferredoxin 5 H+ + NADH + 2 reduced ferredoxin

The enzyme from Thermotoga maritima contains a [Fe-Fe] cluster (H-cluster) and iron-sulfur clusters. I

References

  1. Verhagen, M.F.; O'Rourke, T.; Adams, M.W. (1999). "The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization". Biochim. Biophys. Acta. 1412 (3): 212–229. doi:10.1016/s0005-2728(99)00062-6. PMID 10482784.
  2. Schut, G.J.; Adams, M.W. (2009). "The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production". J. Bacteriol. 191 (13): 4451–4457. doi:10.1128/JB.01582-08. PMC 2698477Freely accessible. PMID 19411328.
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