LGR4

LGR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4
External IDs	MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene ontology Molecular function • signal transducer activity • protein binding • transmembrane signaling receptor activity • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane Biological process • hair follicle development • G-protein coupled receptor signaling pathway • cell differentiation • positive regulation of branching involved in ureteric bud morphogenesis • male genitalia development • metanephric nephron tubule morphogenesis • rhythmic process • metanephric glomerulus development • immune system process • epithelial cell proliferation • Wnt signaling pathway • tube morphogenesis • positive regulation of transcription, DNA-templated • multicellular organism development • cell differentiation involved in metanephros development • intestinal stem cell homeostasis • epithelial cell proliferation involved in renal tubule morphogenesis • circadian rhythm • canonical Wnt signaling pathway involved in metanephric kidney development • digestive tract development • innate immune response • negative regulation of transcription, DNA-templated • signal transduction • positive regulation of canonical Wnt signaling pathway • bone remodeling • circadian regulation of gene expression • spermatogenesis • negative regulation of cytokine secretion • osteoblast differentiation • bone mineralization • negative regulation of toll-like receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55366	107515
Ensembl	ENSG00000205213	ENSMUSG00000050199
UniProt	Q9BXB1	A2ARI4
RefSeq (mRNA)	NM_018490	NM_172671
RefSeq (protein)	NP_060960.2	NP_766259.2
Location (UCSC)	Chr 11: 27.37 – 27.47 Mb	Chr 2: 109.92 – 110.01 Mb
PubMed search	[1]	[2]
Wikidata

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Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.^[3][4] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923.
4. "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Further reading

• Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
• Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.