Leukotriene B4 receptor 1

LTB4R
Identifiers
Aliases	LTB4R, BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7, leukotriene B4 receptor
External IDs	OMIM: 601531 MGI: 1309472 HomoloGene: 22477 GeneCards: LTB4R
Targeted by Drug
etalocib[1]
Gene ontology Molecular function • nucleotide binding • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • leukotriene B4 receptor activity • leukotriene receptor activity • signal transducer activity Cellular component • integral component of membrane • membrane raft • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • movement of cell or subcellular component • leukotriene signaling pathway • muscle contraction • neuropeptide signaling pathway • immune response • signal transduction • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1241	16995
Ensembl	ENSG00000213903	ENSMUSG00000046908
UniProt	Q15722	O88855
RefSeq (mRNA)	NM_181657 NM_001143919	NM_008519
RefSeq (protein)	NP_001137391.1 NP_858043.1	NP_032545.1
Location (UCSC)	Chr 14: 24.31 – 24.32 Mb	Chr 14: 55.77 – 55.77 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.^[4][5][6]

See also

• Eicosanoid receptor
• Etalocib, an antagonist at the leukotriene B4 receptor

References

1. "Drugs that physically interact with Leukotriene B4 receptor 1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics. 37 (2): 187–94. doi:10.1006/geno.1996.0541. PMID 8921391.
5. Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363–7. doi:10.1074/jbc.271.31.18363. PMID 8702478.
6. "Entrez Gene: LTB4R leukotriene B4 receptor".

Further reading

• Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family.". J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062.
• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors.". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.
• Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.". Allergology International. 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.". Nature. 387 (6633): 620–4. doi:10.1038/42506. PMID 9177352.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.". Biochem. J. 335 (1): 15–8. PMC 1219746. PMID 9742207.
• Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
• Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230.
• Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.". J. Immunol. 168 (7): 3570–6. doi:10.4049/jimmunol.168.7.3570. PMID 11907121.
• Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128.
• Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.". Am. J. Pathol. 161 (2): 421–8. doi:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367.
• Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116.
• Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.". Adv. Exp. Med. Biol. 507: 357–61. doi:10.1007/978-1-4615-0193-0_55. PMID 12664610.

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• LTB4R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Receptors, Leukotriene B4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.