Microcystinase

Microcystinase is a protease that selectively degrades Microcystin, an extremely potent cyanotoxin that results in marine pollution and human and animal food chain poisoning. The enzyme is naturally produced by a number of bacteria isolated in Japan and New Zealand. As of 2012, the chemical structure of this enzyme has not been scientifically determined.^[1] The enzyme degrades the cyclic peptide toxin microcystin into a linear peptide, which is 160 times less toxic.^[2] Other bacteria then further degrade the linear peptide.

Refs

↑ "Heterologous expression and characterisation of microcystinase.". Toxicon. 59 (5): 578–86. Apr 2012. doi:10.1016/j.toxicon.2012.01.001. PMID 22326726.
↑ http://www.hindawi.com/journals/isrn.microbiology/2013/596429/

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O

3.4.13	Dipeptidase 1 2 3

3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase

3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II

Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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