Pheophorbide A

Pheophorbide A
Names
IUPAC name
(3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid
Identifiers
15664-29-6
3D model (Jmol) Interactive image
ChEBI CHEBI:38257
ChemSpider 10343120
ECHA InfoCard 100.036.110
EC Number 239-738-5
KEGG C18021
PubChem 5323510
Properties
C35H36N4O5
Molar mass 592.68 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pheophorbide a is the product of chlorophyll breakdown. It is used as a photosensitizer.[1]

Photodynamic therapy (PDT) with several photosensitizers is a promising modality for the treatment of cancer. In this study, the therapeutic effect of PDT using the synthetic photosensitizer pheophorbide a (Pa-PDT) was examined in AT-84 murine oral squamous cell carcinoma (OSCC) cells.

References

  1. Chen, K.; et al. (2009). "Novel photosensitizer-protein nanoparticles for Photodynamic therapy: Photophysical characterization and in vitro investigations". Journal of Photochemistry and Photobiology B: Biology. 96 (1): 66–74. doi:10.1016/j.jphotobiol.2009.04.006.
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