SNX13

SNX13
Identifiers
Aliases SNX13, RGS-PX1, sorting nexin 13
External IDs MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

23161

217463

Ensembl

ENSG00000071189

ENSMUSG00000020590

UniProt

Q9Y5W8

Q6PHS6

RefSeq (mRNA)

NM_015132

NM_001014973

RefSeq (protein)

NP_055947.1

NP_001014973.2

Location (UCSC) Chr 7: 17.79 – 17.94 Mb Chr 12: 35.05 – 35.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[3][4][5]

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Teasdale RD; Loci D; Houghton F; Karlsson L; Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026Freely accessible. PMID 11485546.
  4. Zheng B; Ma YC; Ostrom RS; Lavoie C; Gill GN; Insel PA; Huang XY; Farquhar MG (Nov 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science. 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322.
  5. 1 2 "Entrez Gene: SNX13 sorting nexin 13".

Further reading


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