SNX15

SNX15
Identifiers
Aliases SNX15, HSAF001435, sorting nexin 15
External IDs MGI: 1916274 HomoloGene: 12294 GeneCards: SNX15
Orthologs
Species Human Mouse
Entrez

29907

69024

Ensembl

ENSG00000110025

ENSMUSG00000024787

UniProt

Q9NRS6

Q91WE1

RefSeq (mRNA)

NM_147777
NM_013306

NM_026912

RefSeq (protein)

NP_037438.2
NP_680086.2

NP_081188.1

Location (UCSC) Chr 11: 65.03 – 65.04 Mb Chr 19: 6.12 – 6.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.[3][4]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079.
  4. 1 2 "Entrez Gene: SNX15 sorting nexin 15".

Further reading


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