TSG-6

TNFAIP6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TNFAIP6, TSG-6, TSG6, TNF alpha induced protein 6
External IDs MGI: 1195266 HomoloGene: 5162 GeneCards: TNFAIP6
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

7130

21930

Ensembl

ENSG00000123610

ENSMUSG00000053475

UniProt

P98066

O08859

RefSeq (mRNA)

NM_007115

NM_009398

RefSeq (protein)

NP_009046.2

NP_033424.1

Location (UCSC) Chr 2: 151.36 – 151.38 Mb Chr 2: 52.04 – 52.06 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein[3] that in humans is encoded by the TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) gene.[4][5]

TSG-6 is a 30 kDa secreted protein that contains a hyaluronan-binding LINK domain a and thus is a member of the hyaluronan-binding protein family, also called hyaladherins. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable, covalent complex with inter-alpha-inhibitor (IαI), and thus enhance the serine protease inhibitory activity of IαI, which is important in the protease network associated with inflammation. The expression of this gene can be induced by a number of signalling molecules, principally tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1). The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation.[5]

TSG-6 also interacts with a plethora of matrix associated molecules, such an aggrecan, versican, thrombospondin (1&2), pentraxin-3 and fibronectin.

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Lee TH, Wisniewski HG, Vilcek J (January 1992). "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44". J. Cell Biol. 116 (2): 545–57. doi:10.1083/jcb.116.2.545. PMC 2289279Freely accessible. PMID 1730767.
  4. Lee TH, Klampfer L, Shows TB, Vilcek J (March 1993). "Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein". J. Biol. Chem. 268 (9): 6154–60. PMID 8454591.
  5. 1 2 "Entrez Gene: TNFAIP6 tumor necrosis factor, alpha-induced protein 6".

Further reading


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