Vicenistatin

Vicenistatin
Identifiers
CAS Number 150999-05-6
PubChem (CID) 6438888
ChemSpider 4943331
Chemical and physical data
Formula C30H48N2O4
Molar mass 500.71 g/mol
3D model (Jmol) Interactive image

Vicenistatin is a macrolactam antibiotic synthesized by Streptomyces halstedii HC34. It was originally isolated from this bacterium in 1993.[1] It includes the unusual starter unit methylaspartate.[2]

References

  1. SHINDO, KAZUTOSHI; KAMISHOHARA, MASARU; ODAGAWA, ATSUO; MATSUOKA, MICHIKO; KAWAI, HIROYUKI (1993). "Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic.". The Journal of Antibiotics. 46 (7): 1076–1081. doi:10.7164/antibiotics.46.1076.
  2. Ogasawara, Y.; Kakinuma, K.; Eguchi, T. (2005). "Involvement of Glutamate Mutase in the Biosynthesis of the Unique Starter Unit of the Macrolactam Polyketide Antibiotic Vicenistatin". The Journal of Antibiotics. 58 (7): 468–72. doi:10.1038/ja.2005.62. PMID 16161486.
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