FCGR3B

FCGR3B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1E4J, 1E4K, 1FNL, 1T83, 1T89
Identifiers
Aliases	FCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb, Fc fragment of IgG receptor IIIb
External IDs	MGI: 2179523 HomoloGene: 477 GeneCards: FCGR3B
Gene ontology Molecular function • IgG binding Cellular component • extracellular region • anchored component of membrane • plasma membrane • extracellular exosome • membrane Biological process • immune response • xenophagy • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2215	246256
Ensembl	ENSG00000162747	ENSMUSG00000059089
UniProt	O75015	n/a
RefSeq (mRNA)	NM_001271037 NM_000570 NM_001244753 NM_001271035 NM_001271036	NM_144559
RefSeq (protein)	NP_000561.3 NP_001231682.1 NP_001257964.1 NP_001257965.1 NP_001257966.1	n/a
Location (UCSC)	Chr 1: 161.62 – 161.63 Mb	Chr 1: 171.02 – 171.03 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.^[3]

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.^[4]

See also

• CD16
• Cluster of differentiation

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)".
4. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT (Feb 2006). "Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans". Nature. 439 (7078): 851–5. doi:10.1038/nature04489. PMID 16482158.

Further reading

• Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
• Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW (Feb 1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.
• Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP (Jul 1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.
• Ravetch JV, Perussia B (Aug 1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.
• Simmons D, Seed B (Jun 1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature. 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.
• Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (Jan 1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
• Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (Nov 1996). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
• Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S (Feb 1997). "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb". Blood. 89 (3): 1027–34. PMID 9028335.
• Zocchi MR, Rubartelli A, Morgavi P, Poggi A (Sep 1998). "HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels". Journal of Immunology. 161 (6): 2938–43. PMID 9743356.
• Sondermann P, Huber R, Oosthuizen V, Jacob U (Jul 2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex". Nature. 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521.
• Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD (Sep 2000). "Crystal structure of the extracellular domain of a human Fc gamma RIII". Immunity. 13 (3): 387–95. doi:10.1016/S1074-7613(00)00038-8. PMID 11021536.
• Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T (Sep 2000). "Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen". Tissue Antigens. 56 (3): 272–5. doi:10.1034/j.1399-0039.2000.560310.x. PMID 11034564.
• Bharadwaj D, Mold C, Markham E, Du Clos TW (Jun 2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis". Journal of Immunology. 166 (11): 6735–41. doi:10.4049/jimmunol.166.11.6735. PMID 11359830.
• Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M (Mar 2002). "Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions". The Journal of Allergy and Clinical Immunology. 109 (3): 463–9. doi:10.1067/mai.2002.121952. PMID 11897993.
• Fossati G, Moots RJ, Bucknall RC, Edwards SW (May 2002). "Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes". Arthritis and Rheumatism. 46 (5): 1351–61. doi:10.1002/art.10230. PMID 12115243.
• Cauza K, Grassauer A, Hinterhuber G, Horvat R, Rappersberger K, Wolff K, Foedinger D (Nov 2002). "FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma". The Journal of Investigative Dermatology. 119 (5): 1074–9. doi:10.1046/j.1523-1747.2002.19527.x. PMID 12445195.
• Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K (May 2003). "Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 61 (5): 374–83. doi:10.1034/j.1399-0039.2003.00047.x. PMID 12753656.
• Breij EC, van der Pol WL, van Winsen L, Jansen MD, Dijkstra CD, van de Winkel JG, Uitdehaag BM (Jul 2003). "No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS". Journal of Neuroimmunology. 140 (1-2): 210–5. doi:10.1016/S0165-5728(03)00207-8. PMID 12864991.
• Tong Y, Jin J, Yan L, Neppert J, Marget M, Flesch BK (Sep 2003). "FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province". Annals of Hematology. 82 (9): 574–8. doi:10.1007/s00277-003-0725-y. PMID 12898191.
• Tanaka S, Edberg JC, Chatham W, Fassina G, Kimberly RP (Dec 2003). "Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins". Journal of Immunology. 171 (11): 6090–6. doi:10.4049/jimmunol.171.11.6090. PMID 14634123.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.