ITGA5

ITGA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4
Identifiers
Aliases	ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5
External IDs	MGI: 96604 HomoloGene: 20508 GeneCards: ITGA5
Gene ontology Molecular function • vascular endothelial growth factor receptor 2 binding • virus receptor activity • epidermal growth factor receptor binding • metal ion binding • platelet-derived growth factor receptor binding • integrin binding • protein binding • cell adhesion molecule binding Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • alphav-beta3 integrin-vitronectin complex • membrane • focal adhesion • cell-cell junction • ruffle • plasma membrane • synapse • ruffle membrane • cell surface • integrin complex • endoplasmic reticulum • cytoplasmic vesicle • external side of plasma membrane Biological process • leukocyte cell-cell adhesion • positive regulation of vascular endothelial growth factor receptor signaling pathway • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • endodermal cell differentiation • positive regulation of cell migration • heterotypic cell-cell adhesion • wound healing, spreading of epidermal cells • extracellular matrix organization • memory • cell-cell adhesion mediated by integrin • positive regulation of sprouting angiogenesis • cell-substrate adhesion • cell adhesion • angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • cell-substrate junction assembly • integrin-mediated signaling pathway • viral entry into host cell • viral process • negative regulation of anoikis • leukocyte migration • positive regulation of cell-substrate adhesion • regulation of angiogenesis • cell adhesion mediated by integrin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3678	16402
Ensembl	ENSG00000161638	ENSMUSG00000000555
UniProt	P08648	P11688
RefSeq (mRNA)	NM_002205	NM_010577 NM_001314041
RefSeq (protein)	NP_002196.4	NP_034707.5
Location (UCSC)	Chr 12: 54.4 – 54.42 Mb	Chr 15: 103.34 – 103.37 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[3]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[4]

Interactions

ITGA5 has been shown to interact with GIPC1.^[5]

See also

• Cluster of differentiation
• Integrin

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
4. "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
5. Tani, T T; Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. United States. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

Further reading

• Ruoslahti E (1996). "Integrin signaling and matrix assembly.". Tumour Biol. 17 (2): 117–24. doi:10.1159/000217975. PMID 8658014.
• Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells.". Acta Haematol. 97 (1–2): 13–21. doi:10.1159/000203655. PMID 8980606.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.

External links

• CD49e Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGA5 Info with links in the Cell Migration Gateway