Histamine trifluoromethyl toluidide
Names | |
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IUPAC name
6-[2-(1H-imidazol-5-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide | |
Other names
HTFMT, HTMT | |
Identifiers | |
103827-16-3 | |
3D model (Jmol) | Interactive image |
ChemSpider | 111155 |
1273 | |
PubChem | 124846 |
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Properties | |
C19H25F3N4O | |
Molar mass | 382.42321 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Histamine trifluoromethyl toluidide (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.[1]
It also produces additional actions which appear to be independent of histamine receptors.[2][3]
References
- ↑ Whyment AD, Blanks AM, Lee K, Renaud LP, Spanswick D. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. Journal of Neurophysiology. 2006 Apr;95(4):2492-500. PMID 16354729
- ↑ Qiu R, Melmon KL, Khan MM. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics. 1990 Jun;253(3):1245-52. PMID 2359026
- ↑ Kim DC, Lee SY, Jun DJ, Kim SH, Lee JH, Hur EM, Baek NI, Kim KT. Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors. Biochemical Pharmacology. 2005 Nov 25;70(11):1613-22. PMID 16219299
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