Ion transporter superfamily

Identifiers
Symbol IT
Pfam clan CL0182
OPM superfamily 465
OPM protein 4r1i

The ion transporter (IT) superfamily is made up of secondary carriers specific for cationic and anionic compounds. Families belonging to the IT superfamily have been characterized base upon (1) the known substrates transported, (2) the modes of transport and energy coupling mechanisms used, (3) the family sizes (in numbers of sequenced protein members in the current NCBI database), (4) the organismal distributions of the members of each family, (5) the size ranges of the constituent proteins, (6) the predicted topologies of these proteins, and (7) the occurrence of non-homologous auxiliary proteins that may either facilitate or be required for transport.[1][2]

Families

As of early 2016, the currently recognized and functionally defined families that make up the IT superfamily include:

See also

References

  1. ↑ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
  2. ↑ Chen, Jonathan S.; Reddy, Vamsee; Chen, Joshua H.; Shlykov, Maksim A.; Zheng, Wei Hao; Cho, Jaehoon; Yen, Ming Ren; Saier, Milton H. (2011-01-01). "Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments". Journal of Molecular Microbiology and Biotechnology. 21 (3-4): 83–96. doi:10.1159/000334611. ISSN 1660-2412. PMC 3290041Freely accessible. PMID 22286036.


This article is issued from Wikipedia - version of the 11/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.